Endocrine Abstracts

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patient’s quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patient’s opi...

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...

Background: There is an increasing interest to find specific prognostic markers of the aggressive behaviour of some pituitary adenomas (PA). The most studied markers have been the immunohistochemical staining for Ki-67 and p53. The aim of this study was to evaluate the relevance as possible prognostic markers of growth factors (IGF1R), angiogenic factors (VEGF and his receptor) and new genes (PTTG) versus the immunohistochemical expression of Ki-67 and p53 in PA.<p class="...

Somatostatin receptors (sst1–sst5) comprise a family of G-protein-coupled, 7 transmembrane domain (TMD) receptors encoded by five separate, intronless genes widely distributed throughout the organism. Somatostatin (SST) and cortistatin (CORT), two highly-related cyclic neuropeptides, bind to sst1–sst5 with comparable subnanomolar affinity to exert a number of (patho)physiological actions, from inhibition of endocrine secretions (e.g. GH and insulin), to the control o...

Background: Parathyroidectomy is the only definitive treatment for primary hyperparathyroidism (PHPT). Identifying parathyroid adenomas (PA) before surgery is essential to perform minimally invasive surgery and to achieve higher cure rates.Methods: Retrospective study of patients with PHTP who underwent 18F-Fluorocholine Positron Emission Tomography- Computed Tomography (18FCH-PET-CT) between 2019 and 2021 at our center due to non-localization of PA or d...

Introduction: The majority of current guidelines recommend surgery for benign solid nodules with pressure symptoms or a significant growth. Currently, minimal invasive techniques have emerged such as radiofrequency ablation (RF) which achieve significant volume decrease and many cases, the improvement or disappearance of pressure symptoms.Results: We describe the efficacy and safety of one single-session of RF in our centre performed in thyroid nodules f...

Chimeric somatostatin (SST)/dopamine (DA) compounds, termed dopastatins, such as BIM-23A760, an agonist for SST (sst2 and ss5) and DA (D2) receptors, are emerging as promising new approaches to treat pituitary adenomas. However, their actions and mechanisms on the different types of pituitary tumours are still incompletely understood. Thus, the aim of this study was to analyse a set of key functional parameters (signaling pathways, hormonal expression and secretion, cell viabi...

Somatostatin analogs (SSA) are a first-line treatment for pituitary adenomas (PA). Indeed, multi-receptor targeting SSA such as octreotide and pasireotide are being successfully used to control hormone secretion and/or tumor growth. Unfortunately, many PA escape from SSA-therapy, which could be related to somatostatin receptor (sst) presence, abundance, availability and/or signaling. In order to better define the molecular/cellular features associated to octreotide and pasireo...